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xchange by Pneuma Therapeutics

Patient Selection

Support the airway before obstruction becomes an emergency.

xchange™ is designed for proactive airway stabilization during moderate-to-deep procedural sedation and select TIVA cases when spontaneous ventilation is intended.

The strongest candidates are patients at elevated risk of upper-airway collapse, or cases where clinicians want to reduce escalation to oral airways, LMAs, or intubation.

Who may benefit most?

A clinically useful hierarchy: patient risk, procedural context, and airway-management goal.

01

Elevated airway risk

Patients more likely to lose upper-airway patency as sedation reduces pharyngeal muscle tone.

  • High BMI, obesity, or severe obesity
  • Known or suspected obstructive sleep apnea
  • Difficult airway anatomy or anticipated obstruction
02

Spontaneously breathing cases

Moderate or deep sedation and select TIVA cases in which maintaining spontaneous ventilation is part of the anesthetic plan.

  • Procedures without a planned supraglottic airway
  • Cases where airway instrumentation is undesirable
  • Patients needing titratable positive pressure
03

Higher-consequence settings

Cases where obstruction, hypoxemia, or rescue maneuvers can interrupt the procedure or complicate access to the airway.

  • Shared-airway or limited-access procedures
  • Longer sedation cases
  • Patients with reduced respiratory reserve

Common Procedure Settings

Designed for the gap between oxygen delivery and invasive airway management.

xchange™ provides continuous, titratable nasal CPAP using standard oxygen infrastructure to help maintain patency and ventilation before rescue escalation is required.

GI / endoscopyBronchoscopyElectrophysiologyInterventional radiologyOrthopedic MAC / TIVAOther anticipated obstruction

A better screening conversation

Use a short clinical checklist rather than implying that every diagnosis is, by itself, an indication.

Is upper-airway obstruction anticipated?

Consider anatomy, OSA history, BMI, prior sedation events, and planned depth of sedation.

Will spontaneous ventilation be maintained?

xchange™ is positioned for procedural sedation and select TIVA cases where spontaneous breathing is desired.

Would earlier positive pressure improve the plan?

Consider whether proactive CPAP could reduce jaw thrusts, airway adjuncts, procedural pauses, or escalation.

Is the patient appropriate for a non-invasive strategy?

Final selection, pressure titration, monitoring, and rescue planning remain the responsibility of the treating clinician.

What xchange™ is intended to do

Make the product benefit explicit and clinically grounded.

Maintain upper-airway patency

Positive pressure helps stent open collapsible upper-airway structures during sedation.

Support oxygenation and ventilation

Monitoring goals include SpO₂, ETCO₂ trends, airway patency, and delivered airway pressure.

Enable earlier intervention

The system is positioned before oral airways, LMAs, and other invasive rescue devices in the airway escalation pathway.

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